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Which interface is best to use for connecting the U8?

If your graphics card supports 4K 160Hz output, it is recommended to use the DP interface. The DP interface supports DSC compression technology, with no noticeable difference in image quality before and after compression. This technology is used throughout the 4K high-refresh monitor industry. If your computer supports the Type-C interface, Type-C can also achieve 4K 160Hz. HDMI 2.1 supports up to 4K 144Hz.